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Goat Anti-TRPM5 / MTR1 Antibody

Catalog # Availability Size / Price Inquiry
AMM05958G Discontinued 0.1 mg / $495

Goat Anti-TRPM5 / MTR1 Antibody

Brand

Leading Biology

Catalog Number

AMM05958G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Goat Anti-TRPM5 / MTR1 antibody.

Molecular Weight

131451 Da

Cellular Localization

Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43, ECO:0000255}

Host

Goat

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

GeneID

UniProt ID

Function

Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage- dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.

Form

0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Synonyms

Transient receptor potential cation channel subfamily M member 5, Long transient receptor potential channel 5, LTrpC-5, LTrpC5, MLSN1- and TRP-related gene 1 protein, TRPM5 (HGNC:14323)

Images

AMM05958G (1 μg/ml) staining of Human Pancreas lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Specification

Quantity

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