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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Goat Anti-Phosphodiesterase 4B Antibody

Goat Anti-Phosphodiesterase 4B Antibody

Catalog # Availability Size / Price Inquiry
APR16360G 0.1 mg / $495

Goat Anti-Phosphodiesterase 4B Antibody

Brand

Leading Biology

Catalog Number

APR16360G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Goat Anti-Phosphodiesterase 4B antibody.

Molecular Weight

83343 Da

Host

Goat

Species Reactivity

Mouse

Isotype

IgG

Symbol

DPDE4

GeneID

UniProt ID

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Summary

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Form

0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, E

Synonyms

cAMP-specific 3', 5'-cyclic phosphodiesterase 4B, 3.1.4.53, DPDE4, PDE32, PDE4B, DPDE4

Images

APR16360G (0.5 μg/ml) staining of Mouse Brain Lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

HEK293 overexpressing Human PDE4B (RC211956) and probed with APR16360G (mock transfection in first lane), tested by Origene.

Specification

Quantity

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