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Goat Anti-DOCK1 Antibody

Catalog # Availability Size / Price Inquiry
AMM04959G 0.1 mg / $495

Goat Anti-DOCK1 Antibody

Brand

Leading Biology

Catalog Number

AMM04959G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Goat Anti-DOCK1 antibody.

Molecular Weight

215346 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm. Membrane. Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate.

Host

Goat

Species Reactivity

Human

Isotype

IgG

GeneID

UniProt ID

Function

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.

Summary

This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis.

Form

0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Synonyms

Dedicator of cytokinesis protein 1, 180 kDa protein downstream of CRK, DOCK180, DOCK1

Images

AMM04959G staining (4 μg/ml) of A431 lysate (RIPA buffer, 35 μg total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.

Specification

Quantity

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