> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Calpain-2 AntibodyBrand |
Leading Biology | Catalog Number |
APG02349G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Calpain-2 antibody.
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Molecular Weight |
79995 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
Calpain 2
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Isotype |
Rabbit IgG
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Symbol |
CANPL2
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GeneID |
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UniProt ID |
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Function |
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508).
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Summary |
Calpains are cytosolic, calcium-dependent, cysteine proteases that are ubiquitously expressed in mammalian and avian tissues. Calpain-1 and 2 consist of a common small subunit and a large variable subunit. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF-hand domain IV. Type I calpain requires micromolar amounts of calcium, while type II calpain requires millimolar amounts of calcium.
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Form |
Liquid. In PBS containing 0.02% sodium azide. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Synonyms |
M-Calpain , Calpain 2 , Calpian II , CANPL2 , CANP2 , millimolar-calpain , mCANP , FLJ39928 , CANPml , EC 3.4.22.53
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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