> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Lipocalin-2 AntibodyBrand |
Leading Biology | Catalog Number |
APR08248G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Lipocalin-2 antibody.
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Molecular Weight |
22588 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
Lipocalin-2
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Isotype |
Rabbit IgG
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Symbol |
HNL, NGAL
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GeneID |
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UniProt ID |
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Function |
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
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Summary |
Lipocalin 2 is from a family of proteins that are involved in the transportation of small hydrophobic molecules including steroids, retinoids, bilin and retinods. Lipocalins have been linked to many biolchemical processes such as immune response, pheromone transport, biological prostaglandin synthesis, retinoid binding, and cancer cell interactions.
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Form |
100 μg (0.5 mg/ml) affinity purified rabbit anti-Lipocalin 2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Synonyms |
Lcn2, Lcn 2, Lipocalin2, Lipocalin 2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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