> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > NCS-1 AntibodyBrand |
Leading Biology | Catalog Number |
AMM06571G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NCS-1 antibody.
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Molecular Weight |
21879 Da
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Cellular Localization |
Antigen Cellular Localization:
Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions
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Host |
Rabbit
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Species Reactivity |
Human, Rat
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Target |
NCS-1
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Isotype |
Rabbit IgG
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Symbol |
FLUP, FREQ
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GeneID |
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UniProt ID |
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Function |
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity).
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Summary |
The neuronal calcium sensor (NCS) protein binds to calcium thro μgh EF-hand motifs, are expressed in neurons. They are implicated in the regulation of neurotransmitters released at the neuromuscular junctions. NCS-1 is widely distributed in the brain, spinal cord and dorsal root ganglia. It has been shown to regulate neurosecreation in a calcium-dependent manner, potentiates nitric oxide synthase activity. NCS-1 has been reserved to indicate the protein observed in humans and mammals.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Synonyms |
FREQ , FLUP , NCS1 , ANTI NEURONAL CALCIUM SENSOR 1 , Frequenin , NCS-1
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Images |
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Specification |
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Quantity |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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