> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > TEM-8/ATR1 AntibodyBrand |
Leading Biology | Catalog Number |
AMM05413G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TEM-8/ATR1 antibody.
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Molecular Weight |
62308 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein Note=At the membrane of lamellipodia and at the tip of actin- enriched filopodia. Colocalizes with actin at the base of lamellipodia (By similarity).
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
TEM-8
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Isotype |
Rabbit IgG
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Symbol |
Atr, Tem8
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GeneID |
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UniProt ID |
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Function |
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells (By similarity).
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Summary |
Tumor Endothelial Markers (TEMs, TEM 1-9) are recently identified genes, whose expression is elevated in tumor-associated endothelium. TEMs are barely detectable in normal endothelial cells. TEM8 has been shown to interact with C5 domain of collagen a3(VI), a protein also preferentially expressed in tumor endothelium. It is tho μght that TEM8 may play a role in tumor angiogenesis.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Synonyms |
Tumor Endothelial Marker 8 , TEM-8, TEM8 , ATR , FLJ10601 , FLJ11298 , FLJ21776
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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