> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Jagged 1 AntibodyBrand |
Leading Biology | Catalog Number |
AMM06036G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Jagged 1 antibody.
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Molecular Weight |
134326 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Target |
Jagged 1
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Isotype |
Rabbit IgG
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GeneID |
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UniProt ID |
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Function |
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Enhances fibroblast growth factor- induced angiogenesis (in vitro). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor- induced angiogenesis.
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Summary |
Jagged belongs to the Delta?Serrate?Lag?2 (DSL) family of ligands that activate LIN12/Notch proteins. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged 1is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Mutation in Jagged1 is associated with an autosomal dominant disorder known as Alagille syndrome and Familial Tetralogy of Fallot a form of complex congenital heart disease.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Synonyms |
CD339
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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