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IRS2 Antibody (C-term)

APR08046G Product Datasheet Protocol

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APR08046G		100 μl / $495

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Leading Biology Inc.

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IRS2 Antibody (C-term)

Brand	Leading Biology	Catalog Number	APR08046G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IRS2 antibody (C-term).
Molecular Weight	137334 Da
Cellular Localization	Antigen Cellular Localization: Cytoplasm, cytosol.
Host	Rabbit
Species Reactivity	Human
Immunogen	1309-1338 aa
Target	This IRS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1309-1338 amino acids from the C-terminal region of human IRS2.
Isotype	Rabbit Ig
GeneID	8660
UniProt ID	Q9Y4H2
Function	May mediate the control of various cellular processes by insulin.
Summary	Insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. This protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, IF, E
Dilution	WB~~1:1000 IF~~1:10~50 IHC-P~~1:50~100
Synonyms	Insulin receptor substrate 2, IRS-2, IRS2
Images	Anti-IRS2 Antibody (C-term) at 1:1000 dilution + Hela whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 137 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Fluorescent image of Hela cell stained with IRS2 Antibody (C-term)( APR08046G).Hela cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with IRS2 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor? 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor? 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃).IRS2 immunoreactivity is localized to Cytoplasm significantly. Western blot analysis of anti-IRS2 Antibody (C-term) (Cat. APR08046G) in 293 cell line lysates (35ug/lane). IRS2 (arrow) was detected using the purified Pab.
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