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PTHLH Antibody (N-term)

APR14300G Product Datasheet Protocol

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APR14300G		100 μl / $495

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Leading Biology Inc.

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PTHLH Antibody (N-term)

Brand	Leading Biology	Catalog Number	APR14300G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PTHLH antibody (N-term).
Molecular Weight	20194 Da
Cellular Localization	Antigen Cellular Localization: Cytoplasm. Nucleus. Secreted.
Host	Rabbit
Species Reactivity	Human, Mouse
Immunogen	10-41 aa
Target	This PTHLH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-41 amino acids from the N-terminal region of human PTHLH.
Isotype	Rabbit Ig
Symbol	PTHRP
GeneID	5744
UniProt ID	P12272
Function	Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1- dependent manner through activation of Rac1.
Summary	PTHLH is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, E
Dilution	WB~~1:1000 IHC-P~~1:50~100
Synonyms	Parathyroid hormone-related protein, PTH-rP, PTHrP, Parathyroid hormone-like protein, PLP, PTHrP[1-36], PTHrP[38-94], Osteostatin, PTHrP[107-139], PTHLH, PTHRP
Images	Western blot analysis of lysates from HepG2 mouse NIH/3T3 cell line (from left to right), using PTHLH Antibody (N-term) ( APR14300G). APR14300G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane. Western blot analysis of PTHLH Antibody (N-term) (Cat. APR14300G) in mouse kidney tissue lysates (35ug/lane). PTHLH (arrow) was detected using the purified Pab. PTHLH Antibody (N-term) (Cat. APR14300G) IHC analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PTHLH Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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