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TERF2IP Antibody (C-term)

AMM08162G Product Datasheet Protocol

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AMM08162G		100 μl / $495

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Leading Biology Inc.

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TERF2IP Antibody (C-term)

Brand	Leading Biology	Catalog Number	AMM08162G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TERF2IP antibody (C-term).
Molecular Weight	44260 Da
Cellular Localization	Antigen Cellular Localization: Nucleus. Cytoplasm. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex (By similarity).
Host	Rabbit
Species Reactivity	Human
Immunogen	349-378 aa
Target	This TERF2IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-378 amino acids from the C-terminal region of human TERF2IP.
Isotype	Rabbit Ig
Symbol	DRIP5, RAP1
GeneID	54386
UniProt ID	Q9NYB0
Function	Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
Summary	The gene encodes a protein that is part of a complexinvolved in telomere length regulation. Pseudogenes are present onchromosomes 5 and 22.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, E
Dilution	WB~~1:1000 IHC-P~~1:10~50
Synonyms	Telomeric repeat-binding factor 2-interacting protein 1, TERF2-interacting telomeric protein 1, TRF2-interacting telomeric protein 1, Dopamine receptor-interacting protein 5, Repressor/activator protein 1 homolog, RAP1 homolog, hRap1, TERF2IP, DRIP5, RAP1
Images	TERF2IP Antibody (C-term) (Cat. AMM08162G) western blot analysis in Hela,HepG2,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the TE2IP antibody detected the TE2IP protein (arrow). TERF2IP Antibody (C-term) (AMM08162G)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TERF2IP Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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