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STRA6 Antibody (C-term)

APR07192G Product Datasheet Protocol

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APR07192G		100 μl / $495

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Leading Biology Inc.

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STRA6 Antibody (C-term)

Brand	Leading Biology	Catalog Number	APR07192G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STRA6 antibody (C-term).
Molecular Weight	73503 Da
Cellular Localization	Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein
Host	Rabbit
Species Reactivity	Human, Mouse
Immunogen	586-614 aa
Target	This STRA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-614 amino acids from the C-terminal region of human STRA6.
Isotype	Rabbit Ig
GeneID	64220
UniProt ID	Q9BX79
Function	May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity).
Summary	STRA6 is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9).
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, E
Dilution	WB~~1:1000 IHC-P~~1:50~100
Synonyms	Stimulated by retinoic acid gene 6 protein homolog, STRA6
Images	Western blot analysis of STRA6 Antibody (C-term) (Cat. APR07192G) in Hela cell line lysates (35ug/lane). UBAC1 (arrow) was detected using the purified Pab; Western blot analysis of STRA6 Antibody (C-term) (Cat. APR07192G) in mouse bladder tissue lysates (35ug/lane). STRA6 (arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human hepatocarcinoma with STRA6 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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