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STK33 Antibody (C-term)

Catalog # Availability Size / Price Inquiry
AMM08026G 100 μl / $495

STK33 Antibody (C-term)

Brand

Leading Biology

Catalog Number

AMM08026G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STK33 antibody (C-term).

Molecular Weight

57831 Da

Cellular Localization

Antigen Cellular Localization: Cytoplasm, perinuclear region.

Host

Rabbit

Species Reactivity

Human

Immunogen

476-506 aa

Target

This STK33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-506 amino acids from the C-terminal region of human STK33.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.

Summary

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, E

Dilution

WB~~1:1000 IHC-P~~1:50~100

Synonyms

Serine/threonine-protein kinase 33, STK33

Images

STK33-T481 (Cat. AMM08026G) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the STK33 antibody detected the STK33 protein (arrow).

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Specification

Quantity

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