> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > IMPDH2 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR07999G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality IMPDH2 antibody (Center).
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Molecular Weight |
55805 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:14766016}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03156, ECO:0000269|PubMed:14766016}
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
180-210 aa
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Target |
This IMPDH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-210 amino acids from the Central region of human IMPDH2.
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Isotype |
Rabbit Ig
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Symbol |
IMPD2
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GeneID |
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UniProt ID |
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Function |
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
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Summary |
IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. Its gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, FC, E
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Dilution |
WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
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Synonyms |
Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMP dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD 2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH 2 {ECO:0000255|HAMAP-Rule:MF_03156}, 111205 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPDH-II, IMPDH2 {ECO:0000255|HAMAP-Rule:MF_03156}, IMPD2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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