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SNCB Antibody (C-term)

APR13434G Product Datasheet Protocol

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APR13434G		100 μl / $495

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Leading Biology Inc.

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SNCB Antibody (C-term)

Brand	Leading Biology	Catalog Number	APR13434G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SNCB antibody (C-term).
Molecular Weight	14288 Da
Cellular Localization	Antigen Cellular Localization: Cytoplasm.
Host	Rabbit
Species Reactivity	Human, Mouse
Immunogen	93-122 aa
Target	This SNCB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-122 amino acids from the C-terminal region of human SNCB.
Isotype	Rabbit Ig
GeneID	6620
UniProt ID	Q16143
Function	Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, E
Dilution	WB~~1:1000 IHC-P~~1:50~100
Synonyms	Beta-synuclein, SNCB
Images	Anti-SNCB Antibody (C-term) at 1:1000 dilution + human brain lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 14 kDa Blocking/Dilution buffer: 5% NFDM/TBST. SNCB Antibody (C-term) (Cat. APR13434G) western blot analysis in mouse cerebellum tissue lysates (15ug/lane).This demonstrates the SNCB antibody detected SNCB protein (arrow). SNCB antibody(C-term) (Cat. APR13434G) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SNCB antibody(C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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