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PON2 Antibody (Center)

Catalog # Availability Size / Price Inquiry
AMR09439G 100 μl / $495

PON2 Antibody (Center)

Brand

Leading Biology

Catalog Number

AMR09439G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PON2 antibody (Center).

Molecular Weight

39397 Da

Cellular Localization

Antigen Cellular Localization: Membrane; Peripheral membrane protein

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

74-101 aa

Target

This PON2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-101 amino acids from the Central region of human PON2.

Isotype

Rabbit Ig

GeneID

UniProt ID

Function

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.

Summary

PON2 is a member of the paraoxonase gene family,which includes three known members located adjacent to each otheron the long arm of chromosome 7. The encoded protein isubiquitously expressed in human tissues, membrane-bound, and mayact as a cellular antioxidant, protecting cells from oxidativestress. Hydrolytic activity against acylhomoserine lactones,important bacterial quorum-sensing mediators, suggests the encodedprotein may also play a role in defense responses to pathogenicbacteria. Mutations in this gene may be associated with vasculardisease and a number of quantitative phenotypes related todiabetes.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Dilution

WB~~1:1000 IHC-P~~1:50~100 IF~~1:10~50

Synonyms

Serum paraoxonase/arylesterase 2, PON 2, Aromatic esterase 2, A-esterase 2, Serum aryldialkylphosphatase 2, PON2

Images

PON2 Antibody (Center) (Cat. AMR09439G) western blot analysis in HepG2 cell line lysates (15ug/lane).This demonstrates the PON2 antibody detected PON2 protein (arrow).

PON2 Antibody (Center) (Cat. AMR09439G) western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the PON2 antibody detected PON2 protein (arrow).

PON2 antibody(Center) (Cat. AMR09439G) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PON2 antibody(Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Specification

Quantity

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