> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > TPSAB1 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR10529G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TPSAB1 antibody (Center).
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Molecular Weight |
30515 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted. Note=Released from the secretory granules upon mast cell activation.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
61-87 aa
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Target |
This TPSAB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-87 amino acids from the Central region of human TPSAB1.
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Isotype |
Rabbit Ig
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Symbol |
TPS1, TPS2, TPSB1
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GeneID |
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UniProt ID |
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Function |
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
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Summary |
Tryptases comprise a family of trypsin-like serineproteases, the peptidase family S1. Tryptases are enzymaticallyactive only as heparin-stabilized tetramers, and they are resistantto all known endogenous proteinase inhibitors. Several tryptasegenes are clustered on chromosome 16p13.3. These genes arecharacterized by several distinct features. They have a highlyconserved 3' UTR and contain tandem repeat sequences at the 5'flank and 3' UTR which are thought to play a role in regulation ofthe mRNA stability. These genes have an intron immediately upstreamof the initiator Met codon, which separates the site oftranscription initiation from protein coding sequence. This featureis characteristic of tryptases but is unusual in other genes. Thealleles of this gene exhibit an unusual amount of sequencevariation, such that the alleles were once thought to represent twoseparate genes, alpha and beta 1. Beta tryptases appear to be themain isoenzymes expressed in mast cells; whereas in basophils,alpha tryptases predominate. Tryptases have been implicated asmediators in the pathogenesis of asthma and other allergic andinflammatory disorders.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, FC, E
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Dilution |
WB~~1:1000
FC~~1:10~50
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Synonyms |
Tryptase alpha/beta-1, Tryptase-1, Tryptase I, Tryptase alpha-1, TPSAB1, TPS1, TPS2, TPSB1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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