> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Phospho-Nephrin(Y1210)) AntibodyBrand |
Leading Biology | Catalog Number |
AMM07151G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Nephrin(Y1210)) antibody.
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Molecular Weight |
134742 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
This Nephrin Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1210 of human Nephrin.
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Isotype |
Rabbit Ig
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Symbol |
NPHN
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GeneID |
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UniProt ID |
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Function |
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity).
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Summary |
This gene encodes a member of the immunoglobulin family ofcell adhesion molecules that functions in the glomerular filtrationbarrier in the kidney. The gene is primarily expressed in renaltissues, and the protein is a type-1 transmembrane protein found atthe slit diaphragm of glomerular podocytes. The slit diaphragm isthought to function as an ultrafilter to exclude albumin and otherplasma macromolecules in the formation of urine. Mutations in thisgene result in Finnish-type congenital nephrosis 1, characterizedby severe proteinuria and loss of the slit diaphragm and footprocesses.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
DB, E
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Dilution |
DB~~1:500
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Synonyms |
Nephrin, Renal glomerulus-specific cell adhesion receptor, NPHS1, NPHN
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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