> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Phospho-ACTH(S168) AntibodyBrand |
Leading Biology | Catalog Number |
APR09121G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-ACTH(S168) antibody.
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Molecular Weight |
29424 Da
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Cellular Localization |
Antigen Cellular Localization:
Secreted.
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
This ACTH Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S168 of human ACTH.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates.
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Summary |
This gene encodes a polypeptide hormone precursor thatundergoes extensive, tissue-specific, post-translational processingvia cleavage by subtilisin-like enzymes known as prohormoneconvertases. There are eight potential cleavage sites within thepolypeptide precursor and, depending on tissue type and theavailable convertases, processing may yield as many as tenbiologically active peptides involved in diverse cellularfunctions. The encoded protein is synthesized mainly incorticotroph cells of the anterior pituitary where four cleavagesites are used; adrenocorticotrophin, essential for normalsteroidogenesis and the maintenance of normal adrenal weight, andlipotropin beta are the major end products. In other tissues,including the hypothalamus, placenta, and epithelium, all cleavagesites may be used, giving rise to peptides with roles in pain andenergy homeostasis, melanocyte stimulation, and immune modulation.These include several distinct melanotropins, lipotropins, andendorphins that are contained within the adrenocorticotrophin andbeta-lipotropin peptides. Mutations in this gene have beenassociated with early onset obesity, adrenal insufficiency, and redhair pigmentation. Alternatively spliced transcript variantsencoding the same protein have been described. [provided byRefSeq].
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
DB, E
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Dilution |
DB~~1:500
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Synonyms |
Pro-opiomelanocortin, POMC, Corticotropin-lipotropin, NPP, Melanotropin gamma, Gamma-MSH, Potential peptide, Corticotropin, Adrenocorticotropic hormone, ACTH, Melanotropin alpha, Alpha-MSH, Corticotropin-like intermediary peptide, CLIP, Lipotropin beta, Beta-LPH, Lipotropin gamma, Gamma-LPH, Melanotropin beta, Beta-MSH, Beta-endorphin, Met-enkephalin, POMC
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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