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SEMA6A Antibody (C-term)

APR13253G Product Datasheet Protocol

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APR13253G		100 μl / $495

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Leading Biology Inc.

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SEMA6A Antibody (C-term)

Brand	Leading Biology	Catalog Number	APR13253G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SEMA6A antibody (C-term).
Molecular Weight	114395 Da
Cellular Localization	Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein
Host	Rabbit
Species Reactivity	Human
Immunogen	998-1028 aa
Target	This SEMA6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 998-1028 amino acids from the C-terminal region of human SEMA6A.
Isotype	Rabbit Ig
Symbol	KIAA1368, SEMAQ
GeneID	57556
UniProt ID	Q9H2E6
Function	Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation (By similarity).
Summary	SEMA6A can act as repulsive axon guidance cues. It may play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, E
Dilution	WB~~1:1000 IHC-P~~1:10~50
Synonyms	Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, SEMA6A, KIAA1368, SEMAQ
Images	Western blot analysis of SEMA6A Antibody (C-term) Pab (Cat. APR13253G) pre-incubated without(lane 1) and with(lane 2) blocking peptide in HL-60 cell line lysate. SEMA6A (arrow) was detected using the purified Pab. Western blot analysis of anti-SEMA6A Antibody (C-term)(Cat. APR13253G) pre-incubated with(right lane) and without(left lane) blocking peptide in mouse cerebellum tissue lysate. SEMA6A (arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human brain tissue reacted with SEMA6A antibody (C-term) (Cat. APR13253G), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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