> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > SPRY2 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR13526G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SPRY2 antibody (N-term).
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Molecular Weight |
34688 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor)
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Host |
Rabbit
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Species Reactivity |
Human, Mouse
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Immunogen |
6-35 aa
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Target |
This SPRY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-35 amino acids from the N-terminal region of human SPRY2.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
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Summary |
This gene encodes a protein belonging to the sproutyfamily. The encoded protein contains a carboxyl-terminalcysteine-rich domain essential for the inhibitory activity onreceptor tyrosine kinase signaling proteins and is required forgrowth factor stimulated translocation of the protein to membraneruffles. In primary dermal endothelial cells this gene istransiently upregulated in response to fibroblast growth factortwo. This protein is indirectly involved in the non-cell autonomousinhibitory effect on fibroblast growth factor two signaling. Theprotein interacts with Cas-Br-M (murine) ectropic retroviraltransforming sequence, and can function as a bimodal regulator ofepidermal growth factor receptor/mitogen-activated protein kinasesignaling. This protein may play a role in alveoli branching duringlung development as shown by a similar mouse protein. [provided byRefSeq].
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Protein sprouty homolog 2, Spry-2, SPRY2
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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