> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > CCT4 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR15321G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CCT4 antibody (N-term).
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Molecular Weight |
57924 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
4-32 aa
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Target |
This CCT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human CCT4.
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Isotype |
Rabbit Ig
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Symbol |
CCTD, SRB
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GeneID |
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UniProt ID |
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Function |
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
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Summary |
The chaperonin containing TCP1 (MIM 186980) complex (CCT),also called the TCP1 ring complex, consists of 2 back-to-backrings, each containing 8 unique but homologous subunits, such asCCT4. CCT assists the folding of newly translated polypeptidesubstrates through multiple rounds of ATP-driven release andrebinding of partially folded intermediate forms. Substrates of CCTinclude the cytoskeletal proteins actin (see MIM 102560) andtubulin (see MIM 191130), as well as alpha-transducin (MIM 139330)(Won et al., 1998 [PubMed 9819444]).
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
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Synonyms |
T-complex protein 1 subunit delta, TCP-1-delta, CCT-delta, Stimulator of TAR RNA-binding, CCT4, CCTD, SRB
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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