> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > CYP2D6 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
APR07097G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CYP2D6 antibody (N-term).
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Molecular Weight |
55769 Da
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Cellular Localization |
Antigen Cellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
76-105 aa
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Target |
This CYP2D6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human CYP2D6.
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Isotype |
Rabbit Ig
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Symbol |
CYP2DL1
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GeneID |
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UniProt ID |
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Function |
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
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Summary |
This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and is known tometabolize as many as 20% of commonly prescribed drugs. Itssubstrates include debrisoquine, an adrenergic-blocking drug;sparteine and propafenone, both anti-arrythmic drugs; andamitryptiline, an anti-depressant. The gene is highly polymorphicin the population; certain alleles result in the poor metabolizerphenotype, characterized by a decreased ability to metabolize theenzyme's substrates. The gene is located near two cytochrome P450pseudogenes on chromosome 22q13.1. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
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Synonyms |
Cytochrome P450 2D6, CYPIID6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CYP2DL1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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