> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > RNF19A Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR13132G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RNF19A antibody (Center).
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Molecular Weight |
90696 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
384-413 aa
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Target |
This RNF19A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-413 amino acids from the Central region of human RNF19A.
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Isotype |
Rabbit Ig
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Symbol |
RNF19
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GeneID |
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UniProt ID |
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Function |
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
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Summary |
The protein encoded this gene contains two RING-fingermotifs and an IBR (in between RING fingers) motif. This protein isan E3 ubiquintin ligase that is localized in Lewy bodies (LBs), acharacteristic neuronal inclusion in Parkinson's disease (PD)brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8,but not other ubiquitin-conjugating enzymes. This protein is foundto bind and ubiquitylate synphilin 1 (SNCAIP), which is ainteracting protein of alpha synuclein in neurons, and a majorcomponent of LB. Alternatively spliced transcript variants encodingthe same protein have been reported.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
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Synonyms |
E3 ubiquitin-protein ligase RNF19A, 632-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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