> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > PPP2R5C Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR12969G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PPP2R5C antibody (C-term).
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Molecular Weight |
61061 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Chromosome, centromere.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
465-494 aa
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Target |
This PPP2R5C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human PPP2R5C.
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Isotype |
Rabbit Ig
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Symbol |
KIAA0044
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GeneID |
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UniProt ID |
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Function |
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
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Summary |
The product of this gene belongs to the phosphatase 2Aregulatory subunit B family. Protein phosphatase 2A is one of thefour major Ser/Thr phosphatases, and it is implicated in thenegative control of cell growth and division. It consists of acommon heteromeric core enzyme, which is composed of a catalyticsubunit and a constant regulatory subunit, that associates with avariety of regulatory subunits. The B regulatory subunit mightmodulate substrate selectivity and catalytic activity. This geneencodes a gamma isoform of the regulatory subunit B56 subfamily.Alternatively spliced transcript variants encoding differentisoforms have been identified.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, PP2A B subunit isoform B'-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma, Renal carcinoma antigen NY-REN-29, PPP2R5C, KIAA0044
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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