> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > VPS4B Antibody (C-term)Brand |
Leading Biology | Catalog Number |
AMM08494G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality VPS4B antibody (C-term).
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Molecular Weight |
49302 Da
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Cellular Localization |
Antigen Cellular Localization:
Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Note=Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acutely infected cells
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
304-332 aa
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Target |
This VPS4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-332 amino acids from the C-terminal region of human VPS4B.
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Isotype |
Rabbit Ig
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Symbol |
SKD1, VPS42
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GeneID |
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UniProt ID |
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Function |
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).
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Summary |
The protein encoded by this gene is a member of the AAAprotein family (ATPases associated with diverse cellularactivities), and is the homolog of the yeast Vps4 protein. Inhumans, two paralogs of the yeast protein have been identified. Theformer share a high degree of aa sequence similarity with eachother, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1(suppressor of K+ transport defect 1) has been shown to be a yeastVps4 ortholog. Functional studies indicate that both human paralogsassociate with the endosomal compartments, and are involved inintracellular protein trafficking, similar to Vps4 protein inyeast. The gene encoding this paralog has been mapped to chromosome18; the gene for the other resides on chromosome 16. [provided byRefSeq].
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Vacuolar protein sorting-associated protein 4B, Cell migration-inducing gene 1 protein, Suppressor of K(+) transport growth defect 1, Protein SKD1, VPS4B, SKD1, VPS42
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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