> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > DOK7 Antibody (N-term)Brand |
Leading Biology | Catalog Number |
AMM06947G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DOK7 antibody (N-term).
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Molecular Weight |
53097 Da
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Cellular Localization |
Antigen Cellular Localization:
Cell membrane; Peripheral membrane protein. Cell junction, synapse. Note=Accumulates at neuromuscular junctions
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Host |
Rabbit
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Species Reactivity |
Mouse
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Immunogen |
26-55 aa
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Target |
This DOK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human DOK7.
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Isotype |
Rabbit Ig
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Symbol |
C4orf25
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GeneID |
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UniProt ID |
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Function |
Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
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Summary |
The protein encoded by this gene is essential forneuromuscular synaptogenesis. The protein functions in aneuralactivation of muscle-specific receptor kinase, which is requiredfor postsynaptic differentiation, and in the subsequent clusteringof the acetylcholine receptor in myotubes. This protein can alsoinduce autophosphorylation of muscle-specific receptor kinase.Mutations in this gene are a cause of familial limb-girdlemyasthenia autosomal recessive, which is also known as congenitalmyasthenic syndrome type 1B. Alternative splicing results inmultiple transcript variants.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Protein Dok-7, Downstream of tyrosine kinase 7, DOK7, C4orf25
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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