> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > POFUT1 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR12919G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality POFUT1 antibody (C-term).
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Molecular Weight |
43956 Da
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Cellular Localization |
Antigen Cellular Localization:
Endoplasmic reticulum.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
344-373 aa
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Target |
This POFUT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-373 amino acids from the C-terminal region of human POFUT1.
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Isotype |
Rabbit Ig
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Symbol |
FUT12, KIAA0180
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GeneID |
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UniProt ID |
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Function |
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).
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Summary |
This gene encodes a member of the glycosyltransferaseO-Fuc family. This enzyme adds O-fucose through an O-glycosidiclinkage to conserved serine or threonine residues in the epidermalgrowth factor-like repeats of a number of cell surface and secretedproteins. O-fucose glycans are involved in ligand-induced receptorsignaling. Alternative splicing of this gene results in twotranscript variants encoding different isoforms. [provided byRefSeq].
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
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Synonyms |
GDP-fucose protein O-fucosyltransferase 1, Peptide-O-fucosyltransferase 1, O-FucT-1, POFUT1, FUT12, KIAA0180
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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