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TRIP13 Antibody (C-term)

APR13787G Product Datasheet Protocol

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APR13787G		100 μl / $495

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Leading Biology Inc.

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TRIP13 Antibody (C-term)

Brand	Leading Biology	Catalog Number	APR13787G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRIP13 antibody (C-term).
Molecular Weight	48551 Da
Host	Rabbit
Species Reactivity	Human
Immunogen	363-392 aa
Target	This TRIP13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 363-392 amino acids from the C-terminal region of human TRIP13.
Isotype	Rabbit Ig
Symbol	PCH2
GeneID	9319
UniProt ID	Q15645
Function	Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).
Summary	This gene encodes a protein that interacts with thyroidhormone receptors, also known as hormone-dependent transcriptionfactors. The gene product interacts specifically with the ligandbinding domain. This gene is one of several that may play a role inearly-stage non-small cell lung cancer.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, FC, E
Dilution	WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50
Synonyms	Pachytene checkpoint protein 2 homolog, Human papillomavirus type 16 E1 protein-binding protein, 16E1-BP, HPV16 E1 protein-binding protein, Thyroid hormone receptor interactor 13, Thyroid receptor-interacting protein 13, TR-interacting protein 13, TRIP-13, TRIP13, PCH2
Images	Western blot analysis of lysate from Hela cell line, using TRIP13 Antibody (C-term)(Cat. APR13787G). APR13787G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane. TRIP13 Antibody (C-term) (Cat. APR13787G)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRIP13 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. TRIP13 Antibody (C-term) (Cat. APR13787G) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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