> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > HAX1 Antibody (C-term)Brand |
Leading Biology | Catalog Number |
AMM05300G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HAX1 antibody (C-term).
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Molecular Weight |
31621 Da
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Cellular Localization |
Antigen Cellular Localization:
Mitochondrion. Endoplasmic reticulum. Nucleus membrane. Cytoplasmic vesicle. Sarcoplasmic reticulum
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
161-190 aa
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Target |
This HAX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the C-terminal region of human HAX1.
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Isotype |
Rabbit Ig
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Symbol |
HS1BP1
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GeneID |
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UniProt ID |
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Function |
Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools.
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Summary |
The protein encoded by this gene is known to associatewith hematopoietic cell-specific Lyn substrate 1, a substrate ofSrc family tyrosine kinases. It also interacts with the product ofthe polycystic kidney disease 2 gene, mutations in which areassociated with autosomal-dominant polycystic kidney disease, andwith the F-actin-binding protein, cortactin. It was earlier thoughtthat this gene product is mainly localized in the mitochondria,however, recent studies indicate it to be localized in the cellbody. Mutations in this gene result in autosomal recessive severecongenital neutropenia, also known as Kostmann disease. Twotranscript variants encoding different isoforms have been found forthis gene.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:10~50
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Synonyms |
HCLS1-associated protein X-1, HS1-associating protein X-1, HAX-1, HS1-binding protein 1, HSP1BP-1, HAX1, HS1BP1
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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