> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > NUMB Antibody (N-term)Brand |
Leading Biology | Catalog Number |
AMM06871G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NUMB antibody (N-term).
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Molecular Weight |
70804 Da
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Cellular Localization |
Antigen Cellular Localization:
Membrane; Peripheral membrane protein.
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
1-30 aa
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Target |
This NUMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human NUMB.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.
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Summary |
The protein encoded by this gene plays a role in thedetermination of cell fates during development. The encodedprotein, whose degradation is induced in a proteasome-dependentmanner by MDM2, is a membrane-bound protein that has been shown toassociate with EPS15, LNX1, and NOTCH1. Four transcript variantsencoding different isoforms have been found for this gene.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:50~100
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Synonyms |
Protein numb homolog, h-Numb, Protein S171, NUMB
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Images |
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Specification |
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Quantity |
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| 6 | Leading Biology | APR03502G | IGHG1 Antibody (Center) | 100 μl | Polyclonal Antibodies |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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