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BCL10 Antibody (N-term)

APG02234G Product Datasheet Protocol

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APG02234G		100 μl / $495

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Leading Biology Inc.

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BCL10 Antibody (N-term)

Brand	Leading Biology	Catalog Number	APG02234G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality BCL10 antibody (N-term).
Molecular Weight	26252 Da
Cellular Localization	Antigen Cellular Localization: Cytoplasm, perinuclear region. Membrane raft. Note=Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts
Host	Rabbit
Species Reactivity	Human, Mouse
Immunogen	24-51 aa
Target	This BCL10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human BCL10.
Isotype	Rabbit Ig
Symbol	CIPER, CLAP
GeneID	8915
UniProt ID	O95999
Function	Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
Summary	This gene was identified by its translocation in a case ofmucosa-associated lymphoid tissue (MALT) lymphoma. The proteinencoded by this gene contains a caspase recruitment domain (CARD),and has been shown to induce apoptosis and to activate NF-kappaB.This protein is reported to interact with other CARD domaincontaining proteins including CARD9, 10, 11 and 14, which arethought to function as upstream regulators in NF-kappaB signaling.This protein is found to form a complex with MALT1, a proteinencoded by another gene known to be translocated in MALT lymphoma.MALT1 and this protein are thought to synergize in the activationof NF-kappaB, and the deregulation of either of them may contributeto the same pathogenetic process that leads to the malignancy.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, IF, FC, E
Dilution	WB~~1:1000 IHC-P~~1:50~100 IF~~1:10~50 FC~~1:10~50
Synonyms	B-cell lymphoma/leukemia 10, B-cell CLL/lymphoma 10, Bcl-10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, hCLAP, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, Cellular homolog of vCARMEN, cCARMEN, Cellular-E10, c-E10, Mammalian CARD-containing adapter molecule E10, mE10, BCL10, CIPER, CLAP
Images	BCL10 Antibody (N-term) (Cat. APG02234G) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the BCL10 antibody detected the BCL10 protein (arrow). BCL10 antibody (N-term) (Cat. APG02234G) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the BCL10 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Confocal immunofluorescent analysis of BCL10 Antibody (N-term) ( APG02234G) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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