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MICALL1 Antibody (C-term)

APR17381G Product Datasheet Protocol

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APR17381G		100 μl / $495

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Leading Biology Inc.

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MICALL1 Antibody (C-term)

Brand	Leading Biology	Catalog Number	APR17381G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MICALL1 antibody (C-term).
Molecular Weight	93441 Da
Cellular Localization	Antigen Cellular Localization: Recycling endosome membrane; Peripheral membrane protein. Late endosome membrane. Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6
Host	Rabbit
Species Reactivity	Human
Immunogen	752-781 aa
Target	This MICALL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 752-781 amino acids from the C-terminal region of human MICALL1.
Isotype	Rabbit Ig
Symbol	KIAA1668, MIRAB13
GeneID	85377
UniProt ID	Q8N3F8
Function	Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth.
Summary	MICALL1 may be a cytoskeletal regulator.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, E
Dilution	WB~~1:1000 IHC-P~~1:50~100
Synonyms	MICAL-like protein 1, Molecule interacting with Rab13, MIRab13, MICALL1, KIAA1668, MIRAB13
Images	MICALL1 Antibody (C-term) (Cat. APR17381G) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the MICALL1 antibody detected the LACRT protein (arrow). MICALL1 Antibody (C-term) (Cat. APR17381G) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MICALL1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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