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SLC11A1 Antibody (Center)

Catalog # Availability Size / Price Inquiry
APR10923G  In Stock 100 μl / $545

SLC11A1 Antibody (Center)

Brand

Leading Biology

Catalog Number

APR10923G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SLC11A1 antibody (Center).

Molecular Weight

59872 Da

Cellular Localization

Antigen Cellular Localization: Membrane; Multi-pass membrane protein

Host

Rabbit

Species Reactivity

Human

Immunogen

250-276 aa

Target

This SLC11A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-276 amino acids from the Central region of human SLC11A1.

Isotype

Rabbit Ig

Symbol

LSH, NRAMP, NRAMP1

GeneID

UniProt ID

Function

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

Summary

NRAMP1, also known as SLC11A1, is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as leprosy and tuberculosis, and inflammatory diseases such as Crohn disease and rheumatoid arthritis. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IF, E

Dilution

WB~~1:1000

Synonyms

Natural resistance-associated macrophage protein 1, NRAMP 1, Solute carrier family 11 member 1, SLC11A1, LSH, NRAMP, NRAMP1

Images

Anti-SLC11A1 Antibody (Center) at 1:1000 dilution + human liver lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 60 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

Western blot analysis of SLC11A1 Antibody (Center) (Cat. APR10923G) in CEM cell line lysates (35ug/lane). SLC11A1 (arrow) was detected using the purified Pab.

Specification

Quantity

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