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SEMA3E Antibody (C-term)

APR13240G Product Datasheet Protocol

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APR13240G		100 μl / $545

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Leading Biology Inc.

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SEMA3E Antibody (C-term)

Brand	Leading Biology	Catalog Number	APR13240G
Product Type	Polyclonal Antibodies	Field of Research
Product Overview	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SEMA3E antibody (C-term).
Molecular Weight	89543 Da
Cellular Localization	Antigen Cellular Localization: Secreted.
Host	Rabbit
Species Reactivity	Human, Mouse
Immunogen	737-766 aa
Target	This SEMA3E antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-766 amino acids from the C-terminal region of human SEMA3E.
Isotype	Rabbit Ig
Symbol	Semah, Semh
GeneID	20349
UniProt ID	P70275
Function	Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down- regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation.
Summary	The Semaphorins make up the largest family of axon guidance cues yet described. Semaphorins are divided into 8 classes (classes 3-7 found in vertebrates). Class 3 Semaphorins are secreted, classes 4 through 6 are transmembrane proteins, and class 7 are membrane associated via glycosylphosphatidylinositol (GPI) linkage. They are characterized structurally by a conserved ~400 amino acid sema domain. They are classically described as collapsing factors and mediators of axon repulsion, although they may also act as context-dependent chemoattractants. Semaphorins have been shown to have roles in cardiovascular development and in the regulation of immune cell antigen presentation. Receptors or receptor complexes that mediate semaphorin signaling include proteins of the Neuropilin and Plexin families.
Form	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage & Stability	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Applications	WB, IHC-P, E
Dilution	WB~~1:1000 IHC-P~~1:50~100
Synonyms	Semaphorin-3E, Semaphorin-H, Sema H, Sema3e, Semah, Semh
Images	Western blot analysis of Semaphorin 3E(Sema3e) (C-term) (Cat. APR13240G) in CEM cell line lysates (35ug/lane).Sema3e (arrow) was detected using the purified Pab. Western blot analysis of Semaphorin 3E(Sema3e) (C-term) (Cat. APR13240G) in mouse lung tissue lysates (35ug/lane). Sema3e (arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with Semaphorin 3E(Sema3e) (C-term) (Cat. APR13240G), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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