> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > NAT8 Antibody (Center)Brand |
Leading Biology | Catalog Number |
APR10821G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NAT8 antibody (Center).
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Molecular Weight |
25619 Da
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Cellular Localization |
Antigen Cellular Localization:
Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein Endoplasmic reticulum membrane; Single-pass type II membrane protein
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
110-138 aa
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Target |
This NAT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-138 amino acids from the Central region of human NAT8.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids (PubMed:20392701). This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S- conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).
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Summary |
This protein, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, E
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Dilution |
WB~~1:1000
IHC-P~~1:50~100
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Synonyms |
N-acetyltransferase 8, 231-, Acetyltransferase 2, ATase2, Camello-like protein 1, Cysteinyl-conjugate N-acetyltransferase, CCNAT, NAT8 (HGNC:18069)
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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