> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > ADRA1B Antibody (C-term)Brand |
Leading Biology | Catalog Number |
APR14085G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ADRA1B antibody (C-term).
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Molecular Weight |
56836 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes
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Host |
Rabbit
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Species Reactivity |
Human
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Immunogen |
380-409 aa
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Target |
This ADRA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the C-terminal region of human ADRA1B.
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Isotype |
Rabbit Ig
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GeneID |
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UniProt ID |
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Function |
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
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Summary |
Alpha-1-adrenergic receptors (alpha-1-ARs) are members ofthe G protein-coupled receptor superfamily. They activate mitogenicresponses and regulate growth and proliferation of many cells.There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all ofwhich signal through the Gq/11 family of G-proteins and differentsubtypes show different patterns of activation. This gene encodesalpha-1B-adrenergic receptor, which induces neoplastictransformation when transfected into NIH 3T3 fibroblasts and othercell lines. Thus, this normal cellular gene is identified as aprotooncogene. This gene comprises 2 exons and a single largeintron of at least 20 kb that interrupts the coding region.
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Alpha-1B adrenergic receptor, Alpha-1B adrenoreceptor, Alpha-1B adrenoceptor, ADRA1B
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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