> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > VPS25 Antibody(C-term)Brand |
Leading Biology | Catalog Number |
AMM08703G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality VPS25 antibody(C-term).
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Molecular Weight |
20748 Da
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Cellular Localization |
Antigen Cellular Localization:
Cytoplasm. Endosome membrane. Nucleus, nucleoplasm. Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6
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Host |
Rabbit
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Species Reactivity |
Mouse
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Immunogen |
116-144 aa
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Target |
This VPS25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-144 amino acids from the C-terminal region of human VPS25.
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Isotype |
Rabbit Ig
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Symbol |
DERP9, EAP20
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GeneID |
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UniProt ID |
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Function |
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses.
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Summary |
VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) formESCRT-II (endosomal sorting complex required for transport II), acomplex involved in endocytosis of ubiquitinated membrane proteins.VPS25, VPS36, and SNF8 are also associated in a multiproteincomplex with RNA polymerase II elongation factor (ELL; MIM 600284)(Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001[PubMed 11278625]).
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Form |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, E
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Dilution |
WB~~1:1000
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Synonyms |
Vacuolar protein-sorting-associated protein 25, hVps25, Dermal papilla-derived protein 9, ELL-associated protein of 20 kDa, ESCRT-II complex subunit VPS25, VPS25, DERP9, EAP20
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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