> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Urotensin II Receptor AntibodyBrand |
Leading Biology | Catalog Number |
APR00505G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Urotensin II Receptor Antibody.
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Molecular Weight |
42707 Da
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Host |
Rabbit
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Species Reactivity |
Rat
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Target |
Peptide (C)RPLDTVQRSKGYRK, corresponding to amino acid residues 154-167 of rat UTIIR (Accession P49684).??2nd intracellular loop.
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GeneID |
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UniProt ID |
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Summary |
Urotensin II is a very powerful vasoconstrictive substance.The human Urotensin II receptor (UTIIR) was originally isolated as an orphan receptor (GPR14) in neural and sensory tissues.1,2 Urotensin II is expressed in various human tissues suchas CNS, skeletal muscle, smooth muscle, pancreas, and heart.3-5Binding of Urotensin II to the receptor leads to activation of phospholipase C. The resulting increase in intracellular Ca2+ may cause the contraction of vascular smooth muscle. ERK1/2 phophorylation may also be involved in mediating the biological activities of urotensin II.6 Recently, evidence has accumulated indicating that Urotensin II is also expressed in various kindsof tumor cells such as of adrenal tumors and neuroblastomas.In those cells Urotensin II was reported to stimulate cell growth.7-9Abgent is pleased to offer a highly specific antibody directed against the 2nd cytoplasmic loop of therat UTIIR. Anti-Urontenisn II Receptor antibody (#AG1284) can be used in Western blot anlaysis and immunohistochemical applications, and recognizes UTIIR in rat samples.
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Form |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB
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Dilution |
WB~~1:200-1:2000
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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