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KIRREL2 Antibody

Catalog # Availability Size / Price Inquiry
APR06895G 0.1 mg / $695

KIRREL2 Antibody

Brand

Leading Biology

Catalog Number

APR06895G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KIRREL2 Antibody.

Molecular Weight

Predicted: 64, 70, 78 kDa Observed: 70 kDa

Cellular Localization

Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

KIRREL2; KIRREL2 antibody is human, mouse and rat reactive. At least five isoforms are are known to exist. This antibody is predicted to not cross-react with other members of the KIRREL protein family.

Isotype

IgG

Symbol

NEPH3

GeneID

UniProt ID

Summary

KIRREL2, also known as nephrin-like 3, is a type I transmembrane protein belonging to the immunoglobulin superfamily of cell adhesion molecules (1). KIRREL2 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues (1,2). KIRREL2 has been found to be expressed in beta cells of pancreatic islets and is involved in the regulation of both glomerular and neural development (3,4). Downregulation of KIRREL2 is implicated in several proteinuric diseases (4,5).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of KIRREL2 in 293 cell lysate with KIRREL2 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.

Immunohistochemistry of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 5 μg/ml.

Immunofluorescence of KIRREL2 in human pancreas tissue with KIRREL2 antibody at 20 μg/ml.

Specification

Quantity

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