> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > WAPL AntibodyBrand |
Leading Biology | Catalog Number |
APR06882G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality WAPL Antibody.
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Molecular Weight |
Predicted: 131 kDa Observed: 140 kDa
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Cellular Localization |
Antigen Cellular Localization:
Isoform 2: Nucleus.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
WAPAL; WAPL antibody is human, mouse and rat reactive. At least four isoforms of WAPL are known to exist.
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Isotype |
IgG
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Symbol |
FOE, KIAA0261, WAPL
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GeneID |
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UniProt ID |
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Function |
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
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Summary |
WAPL (wings apart-like), also known as WAPAL or FOE, is a 1,190 amino acid protein that contains one WAPL domain and may play an important role in cell growth (1). It is expressed in an isoform dependent manner in heart, skeletal muscle (isoform 2) and uterine cervix tumor tissue (isoform 1) (1,2,4). WAPL is involved in sister-chromatid adhesion and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits (3,4). WAPL is a new regulator of the development and metastasis of cancerous tissue (4,5).
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, IF, E
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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