> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > DCNP1 AntibodyBrand |
Leading Biology | Catalog Number |
APR06878G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality DCNP1 Antibody.
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Molecular Weight |
Predicted: 27 kDa Observed: 24 kDa
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Cellular Localization |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Particularly on the periphery Colocalizes with corticotropin-releasing hormone (CRH) in parvocellular neurons in the paraventricular nucleus
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
C5orf20; DCNP1 antibody is human, mouse and rat reactive.
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Isotype |
IgG
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GeneID |
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UniProt ID |
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Function |
Binds with and transactivates the corticotropin- releasing hormone (CRH) promoter.
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Summary |
The DCNP1 (dendritic cell nuclear protein 1) gene is specifically expressed in dendritic cells, potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response (1). It is localized mainly in the perinucleus. One of the alleles (A/T) of this gene causes premature translation termination at aa 117 and has been associated with an increased prevalence of major depression in humans (2,3). DCNP1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus (4).
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC-P, IF, E
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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