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DISP2 Antibody

Catalog # Availability Size / Price Inquiry
APR06514G 0.1 mg / $695

DISP2 Antibody

Brand

Leading Biology

Catalog Number

APR06514G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DISP2 Antibody.

Molecular Weight

152003 Da

Cellular Localization

Antigen Cellular Localization: Membrane; Multi-pass membrane protein

Host

Rabbit

Species Reactivity

Human

Target

DISP2; DISP2 antibody is human specific. At least two isoforms of Disp2 are known to exist. DISP2 antibody is predicted to not cross-react with Disp1 or Disp3.

Isotype

IgG

Symbol

DISPB, KIAA1742

GeneID

UniProt ID

Summary

DISP2 Antibody: DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

IHC-P, E

Images

Immunohistochemistry of DISP2 in human small intestine tissue with DISP2 antibody at 5 μg/mL.

Specification

Quantity

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