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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Neuregulin-1 (extracellular) Antibody

Neuregulin-1 (extracellular) Antibody

Catalog # Availability Size / Price Inquiry
APR00522G 50 μl / $695

Neuregulin-1 (extracellular) Antibody

Brand

Leading Biology

Catalog Number

APR00522G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Neuregulin-1 (extracellular) Antibody.

Molecular Weight

70392 Da

Host

Rabbit

Species Reactivity

Human, Mouse

GeneID

UniProt ID

Summary

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Form

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC

Images

Western blot analysis of rat heart lysate (lanes 1 and 4) mouse heart membranes (lanes 2 and 5) and mouse brain lysate (lanes 3 and 6):1-3.Anti-Neuregulin-1 (extracellular) antibody (APR00522G), (1:200).4-6. Anti-Neuregulin-1 (extracellular) antibody, preincubated with the control peptide antigen.

Western blot analysis of human MCF-7 breast adenocarcinoma cell lysate (lanes 1 and 4), human U87-MG glioblastoma cell lysate (lanes 2 and 5) and human MDA-231 breast adenocarcinoma cell lysate (lanes 3 and 6):1-3.Anti-Neuregulin-1 (extracellular) antibody (APR00522G), (1:200).4-6. Anti-Neuregulin-1 (extracellular) antibody, preincubated with the control peptide antigen.

Expression of Neuregulin-1 in rat neocortex Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-Neuregulin-1 (extracellular) antibody (APR00522G), (1:1000), followed by anti-rabbit-biotinylated antibody and streptavidin-Cy3 (red). Neuregulin-1 staining isstrong in processes of various cell types (horizontal arrows) and less intense in neuron-shaped soma (vertical arrows). Nuclei are stained with DAPI (blue).

Specification

Quantity

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