> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > RBBP4 AntibodyBrand |
Leading Biology | Catalog Number |
APR00335G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RBBP4 Antibody.
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Molecular Weight |
47656 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus.
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Host |
Rabbit
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Species Reactivity |
Human, Mouse, Rat
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Target |
RBBP4
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Isotype |
Rabbit IgG
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Symbol |
RBAP48
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GeneID |
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UniProt ID |
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Function |
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
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Summary |
Retinoblastoma associated proteins 46 and 48 (RBAP46 and RBAP48? also known as RBBP7 and RBBP4) were first characterized in?human cells as proteins that bind to the retinoblastoma?(Rb) tumor suppressor protein. Since then, these proteins have been shown to be components of many protein? complexes involved in? chromatin? regulation, including the chromatin? assembly factor 1 (CAF?1) complex and type B histone acetyltransferase complex HAT1, both of which function in chromatin? assembly during DNA? replication. RBAP46 and RBAP48 are also found in the nucleosome?remodeling factor complex?NURF, the nucleosome?remodeling and histone de?acetylation complex NuRD, and the Sin3/HDAC?histone de?acetylation complex. More recently, RBAP46 and RBAP48 were identified as components of the polycomb?repressor complex PRC2, which also contains EED and Ezh2. RBAP46 and RBAP48 bind to the histone fold?region of histone H4 and are believed to target these chromatin remodeling, histone acetylation, and histone de?acetylation complexes to their?histone substrates.
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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