> Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > UHRF2 AntibodyBrand |
Leading Biology | Catalog Number |
APR00332G |
Product Type |
Polyclonal Antibodies | Field of Research |
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Product Overview |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality UHRF2 Antibody.
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Molecular Weight |
89985 Da
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Cellular Localization |
Antigen Cellular Localization:
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00358, ECO:0000269|PubMed:12176013, ECO:0000269|PubMed:23404503}. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity).
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Host |
Rabbit
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Species Reactivity |
Human
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Target |
UHRF2
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Isotype |
Rabbit IgG
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Symbol |
NIRF, RNF107
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GeneID |
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UniProt ID |
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Function |
E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
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Summary |
This gene encodes a nuclear protein?which is involved in?cell cycle regulation. The encoded protein?is a ubiquitin ligase capable?of ubiquinating PCNP?(PEST?containing nuclear protein), and together they may?play?a role?in?tumorigenesis. The encoded protein?contains an NIRF_N domain, a PHD finger, a set? and ring associated (SRA) domain, and a RING finger domain and several?of these domains have been shown to be essential for the regulation of cell?proliferation. This protein?may also have a role in?intranuclear degradation of polyglutamine aggregates. Alternative splicing results in?multiple transcript?variants, some?of which are non?protein?coding. [Provided by RefSeq, Feb 2012].
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Form |
Liquid |
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Storage & Stability |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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Applications |
WB, IHC, IF
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Images |
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Specification |
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Quantity |
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Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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