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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > RNF169 antibody - N-terminal region

RNF169 antibody - N-terminal region

Catalog # Availability Size / Price Inquiry
APR00908G 50 μg / $545

RNF169 antibody - N-terminal region

Brand

Leading Biology

Catalog Number

APR00908G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RNF169 antibody - N-terminal region.

Molecular Weight

77kDa

Cellular Localization

Antigen Cellular Localization: Nucleus, nucleoplasm. Note=Localizes to sites of double- strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products

Host

Rabbit

Species Reactivity

Human, Mouse, Rat, Rabbit, Pig, Horse, Bovine, Guinea Pig, Dog

Symbol

KIAA1991

GeneID

UniProt ID

Function

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair.

Form

Liquid

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Images

WB Suggested Anti-RNF169 Antibody Titration: 0.2-1 μg/ml ELISA Titer: 1:312500 Positive Control: THP-1 cell lysate

Specification

Quantity

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