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Phospho-Ser394 HDAC2 Antibody

Catalog # Availability Size / Price Inquiry
APR03406G 100 μl / $545

Phospho-Ser394 HDAC2 Antibody

Brand

Leading Biology

Catalog Number

APR03406G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Ser394 HDAC2 Antibody.

Molecular Weight

55364 Da

Host

Rabbit

Species Reactivity

Mouse

Target

Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser394 of human HDAC2.

GeneID

UniProt ID

Summary

Histone Deacetylase 2 (HDAC2) is part of a family of histone deacetylases that are responsible for deacetylation of lysine residues in the histone core. HDAC2 is classified as a class I histone deacetylase and is ubiquitously expressed throughout the body (Kee et al, 2008). It has been shown that HDAC2 plays an important role in cardiac hypertrophy (Eom et al, 2011). Phosphorylation of ser394 is responsible for the hypertrophy-associated activation of HDAC2, whereas intrinsic basal activity is maintained by phosphorylation of ser422 and ser424 (EOM et al, 2011).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Dilution

WB~~ 1:1000

Images

Western blot of mouse heart lysate showing specific immunolabeling of the ~55k HDAC2 protein phosphorylated at Ser394 (control). Phosphospecificity is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that the lysate was incubated in λ-Ptase (800 units/1mg protein for 30 min). The immunolabeling is completely eliminated by treatment with λ-Ptase.

Specification

Quantity

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