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Phospho-Ser58 COXIV Antibody

Catalog # Availability Size / Price Inquiry
APR03398G 100 μl / $545

Phospho-Ser58 COXIV Antibody

Brand

Leading Biology

Catalog Number

APR03398G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Ser58 COXIV Antibody.

Molecular Weight

17 KDa

Host

Rabbit

Species Reactivity

Mouse, Rat

Target

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser58 conjugated to KLH.

GeneID

UniProt ID

Summary

COX, also known as cytochrome c oxidase, has 12 subunits that make up the transmembrane mitochondrial protein. Subunit IV has two isoforms; COXIV-1 and COXIV-2 (Huttermann et al., 2001). COXIV-1 is expressed ubiquitously while COXIV-2 is highly expressed in adult lung and low levels in brain and heart (Huttermann et al., 2001). Phosphorylation of amino acid residue ser58 of the COXIV-1 protein is a PKA-dependent regulation of COX and plays an important role in metabolism and CREB cycle activation (Acin-Perez et al., 2011).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Dilution

WB~~ 1:1000

Images

Western blot of rat mitochondrial lysate showing specific immunolabeling of the ~17k COXIV phosphorylated at Ser58 (Control). Immunolabeling is blocked by the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown).

Specification

Quantity

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