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Location: Home > Antigen, Antibodies, ELISA, Western Blot > Primary Antibody > Polyclonal Antibodies > Phospho-Ser535,539 Interferon-α Receptor, Type I, Subunit I Antibody

Phospho-Ser535,539 Interferon-α Receptor, Type I, Subunit I Antibody

Catalog # Availability Size / Price Inquiry
APR03385G 100 μl / $545

Phospho-Ser535,539 Interferon-α Receptor, Type I, Subunit I Antibody

Brand

Leading Biology

Catalog Number

APR03385G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Ser535,539 Interferon-α Receptor, Type I, Subunit I Antibody.

Molecular Weight

110-130 KDa

Host

Rabbit

Species Reactivity

Rat

Target

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539 conjugated to KLH.

GeneID

UniProt ID

Summary

Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron, 2001; Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB

Dilution

WB~~ 1:1000

Images

Western blot of immunoprecipitates from HEK 293 cells transfected with 1. Mock, 2. IFNAR1 WT, and 3. IFNAR1 S535A and S539A mutants showing specific immunolabeling of the ~110k to ~130k IFNAR1 WT. The immunolabeling is absent in IFNAR1 Ser535 and Ser539 mutants (Control). The immunolabeling is blocked by the phosphopeptide (Phos) used as the antigen but not by the corresponding dephosphopeptide (Dephos).

Specification

Quantity

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